Ten hub genes associated with exosomes (FTCD, FGA, PLG, HRG, C8A, KLKB1, ANG, C6, ALDH8A1, and C8B) were screened out, among which FTCD was emerged as the key potential exosome-related biomarker having potential value for the diagnosis and prognosis of HCC. This evidence concerns the gene ALDH8A1 and hepatocellular carcinoma.