These results showed that FLT and FBT alleviated lipid metabolism disorder in HFD-induced obese mice by down-regulating the expression of lipid synthesis (SREBP-1c, ACC, and FAS)-related genes and up-regulating the expression of fatty acid oxidation (PPARα)-related genes involved in AMPK signaling pathways. The gene discussed is SREBF1; the disease is Disorder of lipid metabolism.