TAC1 and obesity due to melanocortin 4 receptor deficiency: Among them, namely Tac1 encoding SP and NKA, Tac3 encoding NKB, and Tac4 encoding HK-1 or EKs [9], Tac1 encoding product SP plays an important role in a variety of physiological behaviors such as pain perception [10], neurogenic inflammation [11], smooth muscle contraction [12,13] and obesity regulation [14].