For example, adipose tissue HMGCR gene expression activities were up-regulated at most candidate time points, suggesting that dexamethasone could induce synthesis of sterol lipids of AT to achieve SIIS, which was similar to the up-regulation of HMGCR gene expression in the liver followed stress, thus induced hypercholesterolemia [30,31,32]. Here, HMGCR is linked to familial hypercholesterolemia.