Chen et al. identified two regulatory relationships between SREBP1 and ACSL4 in hepatocellular carcinoma cells: (1) direct binding of c-Myc to the promoter region of the SREBP1 gene, resulting in transcriptional activation of SREBP1 expression; and (2) regulation of the stability of the SREBP1 protein through the F-box and WD repeat domain containing 7 (FBW7) [65]. The gene discussed is ACSL4; the disease is hepatocellular carcinoma.