MMRN1 and pulmonary fibrosis: Therefore, FOXO4-DRI can not only eliminate aging cells and reduce inflammatory stimulation to neighboring cells to ameliorate pulmonary fibrosis (PF) induced by bleomycin (BLM) but can also downregulate the expression of the major ECM genes and proteins, reduce the formation of ECM, and ultimately inhibit ECM–receptor interactions, thus alleviating PF induced by BLM [54].