The GO and KEGG enrichment analysis showed that most DEGs genes were mainly involved in biological processes, molecular function and cellular component, which focus on metabolic pathways, the AMPK signaling pathway, Alzheimer’s disease, endocytosis, the PI3K/Akt/mTOR signaling pathway and focal adhesion (Figure 2B,C). Here, AKT1 is linked to early-onset autosomal dominant Alzheimer disease.