However, Reiner et al. showed that family history of breast cancer remains a strong risk factor for CBC, even after excluding carriers of deleterious mutations in BRCA1, BRCA2, ATM, CHEK2 or PALB2, and after adjusting for 67 common breast cancer-susceptibility single nucleotide polymorphisms (SNPs) [26]. The gene discussed is CHEK2; the disease is breast cancer.