IL-1β secreted by TAMs inactivates GSK3β phosphorylation by activating the NF-κB and AKT signaling pathways, thereby abrogating the β-catenin destruction complex and activating the Wnt/β-catenin signaling pathway in CRC cells [164] (Fig. 6E). This evidence concerns the gene NFKB1 and colorectal carcinoma.