DCLK1 and intestinal neoplasm: Chandrakesan P et al. isolated DCLK1+ cells from the intestines of APCmin/+ mice and found that the CSC markers Lgr5, Bmi1 and Musashi1 were highly expressed in DCLK1+ cells, and the activities of β-catenin, Notch and NF-kB pathways were highly activated, which were all related to the occurrence of intestinal tumors [49].