Additionally, the EWSR1/FUS::NFATC2 gene rearrangement feature can also be detected in simple bone cysts [26], but it does not harbour the amplification of the fusion gene and exhibits different clinical manifestations, histology, and prognosis compared to EWSR1/FUS::NFATC2 sarcoma. The gene discussed is EWSR1; the disease is sarcoma.