EPAS1 and intervertebral disk degenerative disorder: In summary, this study pioneered the development of a promising delivery system, PP20 loaded with PT2399, with sustained release drug effects by a method. PT2399 load PP20 effectively regulates the hypoxic environment and angiogenesis in nucleus pulposus cells, thereby treating disc degeneration, as evidenced by the differential expression of HIF-2α and other genes in human normal and degenerated nucleus pulposus tissues.