EPAS1 and lumbar disk degenerative disorder: On the other hand, eliminating HIF-2α has been found to decrease fibrosis [11], although the exact mechanism of its regulation is still unknown.Further exploration into the regulation of oxygen levels in the nucleus pulposus could potentially unveil novel avenues for future treatments targeting degenerative lumbar disc disease.Hence, it is crucial to acquire understanding of the regulation of HIF-2α and its associated mechanisms in nucleus pulposus cells while experiencing degeneration.