AKT1 and neoplasm: In addition, further Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEGs in the tumor and corresponding paratumor tissues showed that, compared to paratumor tissues, DEGs in DDRPLS were mainly enriched in pathways such as ribosomes, metabolic pathway, PI3K-Akt signaling pathway, cell adhesion molecules (CAMs), phagosome, and pathways in cancer (Fig. 7).