HNRNPA2B1 and early-onset autosomal dominant Alzheimer disease: However, different members of the hnRNP family are associated with a variety of degenerative diseases including multisystem proteinopathy (MSP, hnRNPA1/A2), hereditary motor neuropathy (hnRNPA1), oculopharyngeal muscular dystrophy (hnRNPA2), spinal muscular atrophy (hnRNPG/Q/M/A1/R), Alzheimer’s disease (AD) (hnRNPA1/C/Q), ALS/FTD (hnRNPH/F/A1/A2/A3/E2/D/G/I/L/Q/R), multiple sclerosis (hnRNPA1/H), congenital myasthenic syndrome (hnRNPH/L), and fragile X-associated tremor/ataxia syndrome (hnRNPA2) [7, 143, 152, 153].