KPNB1 and amyotrophic lateral sclerosis: Nup62, an FG-Nup that promotes TDP-43 proteinopathy [278], and KPNB1 colocalize with pTDP-43-positive inclusions in postmortem CNS tissue of ALS/FTD patients [42, 253], and Nup62 overexpression increased the recruitment of KPNB1 to cytoplasmic TDP-CTF aggregates [42].