TARDBP and amyotrophic lateral sclerosis: Two fatal neurodegenerative disorders, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), reside at opposite ends of a continuum of disease states that share underlying genetics, clinical features, and the characteristic accumulation of TAR DNA-binding protein-43 (TDP-43) or other nuclear RNA-binding proteins (RBPs) in detergent-insoluble aggregates in the cytoplasm [3].