FET proteins, hnRNPA1, and hnRNPA2 are depleted from the nucleus and mislocalized to the cytoplasm in stable inclusions in postmortem brain tissue of patients with some forms of familial and sporadic ALS/FTD [127, 146–148, 154, 155]. Here, HNRNPA2B1 is linked to amyotrophic lateral sclerosis.