It has also been documented that the proportions of annexin V+/CD41a+ EVs increase in plasma with disease activity of RA and systemic lupus erythematosus that are both autoimmune-driven inflammatory disorders [27], and that CD9 and CD81 can participate in OA and RA development in animal models [28, 29]. The gene discussed is ANXA5; the disease is rheumatoid arthritis.