3D spherical models of ovarian cancer have been used to shed light on the impact of both integrin beta-6 (ITGB6) and SET and MYN-domain containing 3 (SMYD3) on the activation of the TGFβ1/Smad3 pathway and downstream upregulation of N-cadherin and downregulation of E-cadherin [171]. The gene discussed is SMYD3; the disease is ovarian cancer.