SMN1 and amyotrophic lateral sclerosis: Although a meta-analysis from 2014 [68] confirmed the role of SMN1 duplications as a risk factor of ALS, a recent bioinformatics study, using the DNA sequences of Project MinE (https://www.projectmine.com/) found no association between ALS and the copy number variations of either the SMN1 or the SMN2 gene [69].