NIPA1 and amyotrophic lateral sclerosis: Later the ALS associated role of NIPA1 polymorphic GCG repeat expansions was confirmed in multiple European populations and longer alleles were associated with shorter survival of patients [58]: a large international cohort examining almost 4000 ALS patients found NIPA1 alleles with more than 8 GCG units a risk factor of ALS with an odds ratio of 1.54 [59].