The genotypic and phenotypic characteristics of MPZL2 were analyzed more systematically by summarizing the findings of all the patients carrying MPZL2 variants from this study and those reported in the previous studies, and we found apart from moderate HL, progressive HL is another character of MPZL2-related HL, which proposes the importance of pre-warning risk factors in order to arrest or put off the development of HL in patients. The gene discussed is MPZL2; the disease is Hodgkins lymphoma.