Three anti CD19 CAR-T cell products are currently available in Italy, as third or subsequent line treatment, for refractory/relapsed ALL (tisagenlecleucel), third line treatment for diffuse large B cell lymphomas (either de novo or transformed), high grade B cell lymphomas, transformed follicular lymphomas (axicabtagene ciloleucel, and tisagenlecleucel), primary mediastinal B cell lymphomas (axicabtagene ciloleucel) and for mantle cell lymphomas (brexucabtagene autoleucel) [8]. The gene discussed is CD19; the disease is B-cell non-Hodgkin lymphoma.