Furthermore, to demonstrate the importance of hub genes, we screened a series of genes, including TET2, DNMT3A, ASXL1, EZH2, SF3B1, SRSF2, U2AF1, ZRSR2, RUNX1, TP53, STAG2, NRAS, CBL, NF1, which had been shown to influence the procedure of MDS, for correlation analysis. The gene discussed is CBL; the disease is myelodysplastic syndrome.