To predict the role of hub genes, we screened a series of genes that have been shown to influence the process of MDS, such as TET2, DNMT3A, ASXL1, EZH2, SF3B1, SRSF2, U2AF1, ZRSR2, RUNX1, TP53, STAG2, NRAS, CBL, NF1, for correlation analysis. The gene discussed is ASXL1; the disease is myelodysplastic syndrome.