To predict the role of hub genes, we screened a series of genes that have been shown to influence the process of MDS, such as TET2, DNMT3A, ASXL1, EZH2, SF3B1, SRSF2, U2AF1, ZRSR2, RUNX1, TP53, STAG2, NRAS, CBL, NF1, for correlation analysis. This evidence concerns the gene SF3B1 and myelodysplastic syndrome.