Intercellular adhesion molecule 1 (ICAM1), lamin A (LMNA; cleaved D230), annexin II (ANXA2), focal adhesion kinase I (PTK2Y576/577), and annexin I (ANXA1) were the most highly correlated proteins in ET, whereas syndecan I (SDC1), mitogen activated protein kinase 8 (MAPK8T183/Y185), proto-oncogene tyrosine-protein kinase Src (SRCY416), tyrosine-protein kinase JAK1 (JAK1Y1022/1023), and protein kinase C beta type (PRKCBS600) were the most negatively correlated. The gene discussed is MAP3K8; the disease is essential thrombocythemia.