Particularly, it has been confirmed that ACTB (actin beta) (ranked the 3th in patient TCGA-E2-A158 and the 5th in patient TCGA-BH-A1EU), is distinctly associated with the metastatic ability of human colon adenocarcinoma cells [50] and accumulating evidence demonstrates that ACTB is irregularly expressed in a variety of cancers and affects the metastasis and invasiveness of tumors [51]. The gene discussed is ACTB; the disease is cancer.