Neutrophil extracellular traps (NETs), which was highly expressed in ALI patients and sepsis-induced ALI mice models, were found to increase m6A modification level, hence resulting in ferroptosis and impaired autophagic flux by targeting HIF-1α and Sirt1 in alveolar epithelial cells, suggesting significant roles RNA m6a methylation playing in ALI (Qu et al. 2022; Zhang et al. 2022a). The gene discussed is HIF1A; the disease is acute respiratory distress syndrome.