The mRNA levels of CYB5R3 in the NSCLC cell lines A549, H1299, H1703, H226, H23, H460, H2009, and HCC827 were lower than those in the normal lung fibroblast lines WI-38 and IMR-90 (Fig. 1d). Here, CYB5R3 is linked to non-small cell lung carcinoma.