Finally, the pro-autophagic BECN1 gene expression was significantly (p ≤ 0.05) downregulated in DXN-CSNP, PL-CSNP, PL + DXN, Kmp, and Kmp + DXN groups as compared to the untreated EST-tumor group (Fig. 3D). The gene discussed is BECN1; the disease is neoplasm.