Furthermore, tumors of HPV-ind PDXs treated with BYL719 displayed reduced staining of Ki67, and increased staining of cleaved caspase3 and γH2AX, indicating that BYL719 had superior effect on inhibiting tumor proliferation, promoting tumor apoptosis and DNA damage in HPV-ind PDXs than that with HPV-asso PDXs (Fig. 5H). This evidence concerns the gene MKI67 and neoplasm.