The prognostic impact of mitochondrial complexes was validated in the TARGET AML cohort, which demonstrated that higher expression of NDUFA12 (P = 0.076) and NDUFB6 (P = 0.013) also correlated with shorter EFS in CEBPA-mutated patients (Supplementary Fig. 9). Here, NDUFB6 is linked to acute myeloid leukemia.