These signaling pathways, including Pathways in cancer (hsa05200), PI3K-Akt pathway (hsa04151), MAPK pathway (hsa04010), Rap1 pathway (hsa04015), AGE-RAGE pathway in diabetic complications (hsa04933), Ras pathway (hsa04014), Foxo pathway (hsa04068), HIF-1 pathway (hsa04066), Estrogen signaling pathway (hsa04915), among others, were related to cancer. The gene discussed is RENBP; the disease is cancer.