In cells where infection with CRE particles abolished Chrna7 expression, the KET-induced CREB activation remained unchanged, but effect of HNK was completely abolished (Fig. 6C, D; CTRL-CRE:0.97 ± 0.04; KET-CRE:1.34 ± 0.03; HNK-CRE: 1.0 ± 0.03). This evidence concerns the gene CREB1 and infection.