Besides, we confirmed that HFE145 cells could express Lewisb antigens, with the human gastric adenocarcinoma cell line AGS that has been reported to express Lewisb as a positive control48, and by knocking down two genes responsible for the biosynthesis of Lewisb antigens (i.e., FUT2 and FUT3) as a negative control50 (Supplementary Fig. 12b–d). The gene discussed is FUT3; the disease is gastric adenocarcinoma.