While some genes may contribute to a specific phenotype [e.g., upregulation of Hap1 (huntingtin associated protein 1) leading to detrimental effects on cell survival], others may have more overarching regulatory roles [e.g., downregulation of Grin2b (glutamate ionotropic receptor NMDA type subunit 2B) resulting in predicted inhibition of excitatory postsynaptic potentials, learning, and memory, and predicted activation of anxiety and neuronal cell death pathways]. The gene discussed is HAP1; the disease is Anxiety.