IL1B and inflammatory bowel disease: This finding is in agreement with clinical studies suggesting that MN‐derived TNF‐α and IL‐1β are high‐level drivers of intestinal inflammation in IBD.[110, 111] We showed that iDCs properly matured, underwent activation, and exhibited apical antigen sampling functions, as inflammatory stimuli induced higher levels of GM‐CSF in IEB model‐iDC co‐cultures (Figure 6b‐iii).