These domains can also form from through inhibition of enzymatic cholesterol esterification and oxidative modification of the membrane.136,150–153 Inhibition of cholesterol domain formation may attenuate atherosclerosis, as cholesterol crystals can contribute to fibrous cap puncture, NLR family pyrin domain containing 3 (NLRP3) inflammasome activation, cytokine release, inflammatory cell activation and recruitment, eNOS inhibition and oxidative stress following angiotensin II challenge, and tissue injury.152,154–159. Here, NLRP3 is linked to atherosclerosis.