One of the two RCTs had a high risk of bias; participants were aware of their allocation and 5/40 GPs in the control group dropped out after randomization.35 Reason for declining to participate was not reported; however, participants may have declined after randomization as they would not receive the C-reactive protein testing kits given to the intervention group (not readily available in Latvian general practice).35 Participants recorded their own prescribing, and were not required to record all consultations for infections. Here, CRP is linked to infection.