Toxicity was defined as nephrotoxicity (serum creatinine of ≥0.5 mg/dL or doubling of baseline value), hypokalaemia (potassium of ≤3.0 mmol/L or ≥50% from baseline), anaemia (haemoglobin of ≤8.0 g/dL) and hepatoxicity (rise in bilirubin by ≥1.5 mg/dL or AST or ALT ≥3 times above baseline). Here, GPT is linked to nephrotoxicity.