Somatic mutations in DICER1 RNase IIIb hotspots have been shown in a wide variety of RAS-like lesions, ranging from benign FTA (23), NIFTP (30), to malignant FTC (22) and FVPTCs (12), highlighting an association to early- and adult-onset thyroid lesions with a favorable prognosis (31, 32). The gene discussed is DICER1; the disease is thyroid cancer, nonmedullary, 2.