Somatic mutations in DICER1 RNase IIIb hotspots have been shown in a wide variety of RAS-like lesions, ranging from benign FTA (23), NIFTP (30), to malignant FTC (22) and FVPTCs (12), highlighting an association to early- and adult-onset thyroid lesions with a favorable prognosis (31, 32). This evidence concerns the gene DICER1 and Adult onset.