Interestingly, one of the models suggestedthat although neurodegeneration was not seen, there was increasedOS and increased risk of cancer.72 Similarto SOD2, SLC30A10, and ATP13A2, are related to Mn,73,74 and Mn is an important element for neuronal health,75,76 which can cross the blood–brain barrier (BBB).77 Furthermore, dysfunction of Mn-related proteins(ATP13A2, SLC30A10, and SOD2) can increase neuronal damage in stresscontexts. This evidence concerns the gene SOD2 and cancer.