SOD2, also knownas manganese (Mn)-dependent superoxide dismutase, is located in themitochondrial matrix and is an enzyme protective against OS.71 SOD2 was linked to cognitive deficits aftermild acute ischemic stroke in early 2022.51 Several animal models, including mice, with SOD2 deficiency wereused as models for neurodegenerative diseases. Here, SOD2 is linked to Cognitive impairment.