TPX2 and hepatocellular carcinoma: Other differentially expressed genes implemented in hepatic stem cell activation and HCC oncogenesis affected by treatment with proglumide in DDC-fed mice are shown in Supplemental Fig. S7, A–D. In particular, genes downregulated with proglumide in DDC-fed mice that are involved with liver stem cell activation are shown in Supplemental Fig. S7A including several genes involved in the WNT/β-catenin pathway and genes implicated in the hedgehog pathway, such as TPX2 and FOXM1.