CCKBR and Hepatic fibrosis: Similarly, liver fibrosis was significantly less in DDC-fed CCK-BR-KO mice (Fig. 2M) compared with DDC-fed wild-type (Fig. 2K) or heterozygous mice (Fig. 2L) in the transgenic model study C. This difference was quantitatively significant in the histologic area analysis (Fig. 2N).