PSB0777 treatment significantly restores AC, cAMP, PKA, and hormone-sensitive lipase (HSL) levels, decreased <i>SREBP-1/FASN</i>, MCP-1, and CD68 levels, reduces infiltrated CD11b<sup>+ </sup>F4/80<sup>+</sup> cells and adipogenesis in VAT of NASH + PSB0777 mice. This evidence concerns the gene SREBF1 and metabolic dysfunction-associated steatohepatitis.