Herein, our findings suggested that 1) MIR205HG, JMJD2C, and ALKBH5 were highly expressed in melanoma; 2) MIR205HG may stabilize JMJD2C expression by binding to HuR; 3) JMJD2C may reduce the occupation of H3K9me3 in the ALKBH5 promoter to promote ALKBH5 transcription, thus boosting proliferation, invasion, and migration of melanoma cells (Fig 8). Here, ALKBH5 is linked to melanoma.