In essence, our finding demonstrated that MIR205HG may stabilize JMJD2C expression via binding to HuR and reduce the occupation of H3K9me3 in the ALKBH5 promoter to promote ALKBH5 transcription, thus promoting proliferation, invasion, and migration of melanoma cells, and MIR205HG downregulation suppresses tumor growth in vivo via repressing the JMJD2C/ALKBH5 axis. The gene discussed is MIR205HG; the disease is neoplasm.