KDM4C and melanoma: Herein, our findings suggested that 1) MIR205HG, JMJD2C, and ALKBH5 were highly expressed in melanoma; 2) MIR205HG may stabilize JMJD2C expression by binding to HuR; 3) JMJD2C may reduce the occupation of H3K9me3 in the ALKBH5 promoter to promote ALKBH5 transcription, thus boosting proliferation, invasion, and migration of melanoma cells (Fig 8).