The finding that Slc4a11 knockout mice have approximately the same CEnC density as wild type mice at 10 weeks of age, but exhibit a significantly lower CEnC density by 40 weeks of age, suggests that decreased CEnC viability may be the cause of the congenital corneal edema in individuals with CHED [55]. The gene discussed is SLC4A11; the disease is congenital hereditary endothelial dystrophy of cornea.