SLC4A11 and congenital hereditary endothelial dystrophy of cornea: However, unlike most of the CHED-associated SLC4A11 mutations examined in this study, FECD4-associated mutation c.2224G>A (Gly742Arg) (and variant 3 equivalent c.2176G>A (Gly726Arg)) also did not demonstrate significant changes in CEnC viability under oxidative stress when compared to their wild type counterparts, which means additional studies are needed to parse out the impact of these FECD-associated SLC4A11 mutations on cell viability.