Similar to CEnC harboring CHED-associated SLC4A11 mutations, CEnC harboring the FECD4-associated mutation c.2224G>A (Gly742Arg) (and variant 3 equivalent c.2176G>A (Gly726Arg)) did not exhibit any significant increases in cell viability during tBH-induced oxidative stress when compared to SLC4A11-/- empty CEnC, suggesting both CHED- and FECD4-associated SLC4A11 mutations lead to a loss of oxidative stress protection similar to that of the SLC4A11 empty CEnC. This evidence concerns the gene SLC4A11 and congenital hereditary endothelial dystrophy of cornea.