Peptidylprolyl isomerase A (PPIA), a.k.a. as cyclophilin A, has been related with ERK1/2 phosphorylation and NF-κB activation [41], gastrin cancer serum biomarker [42] and poor prognosis in hepatocellular carcinoma [43]. This evidence concerns the gene MAPK3 and hepatocellular carcinoma.