Although previous studies have reported the protective role of ARRB1 in many liver diseases, such as non-alcoholic steatohepatitis, liver ischemia/reperfusion injury, and lipopolysaccharide-induced acute liver injury, there is no report about the role of ARRB1 in APAP-induced liver injury (Xu et al. 2020; Zhang et al. 2020; Lei et al. 2021). The gene discussed is ARRB1; the disease is metabolic dysfunction-associated steatohepatitis.