Moreover, AIM2 and IFI16 filaments also persist and are even stigmatized as autoantigens in debilitating autoimmune disorders such as systemic lupus erythematosus and Sjögren’s syndrome (Antiochos et al., 2018; Antiochos et al., 2022; Baer et al., 2016). Here, AIM2 is linked to Sjogren syndrome.