TP53 and cancer: Given that it is a hypomorphic (i.e. multiple descriptions of p53 downregulation in clinical samples and cancer cell lines harboring the minor C-allele) and rare variant (MAF ranging from 0.002 to 0.02 in African and European populations, respectively), there are only a few reports of rs78378222[C/C] homozygotes in previous studies and different population databases (Table S3).