As shown in Table 1, the PCOS group had significantly higher WC, waist-to-hip ratio, acne grade score, F-G score, DBP, average ovarian volume, TT, FAI, LH, LH/FSH ratio, fasting Ins, HOMA-IR, 2 h-Ins and Glu, TC, LDL-C, TG, apoB, apoB/apoA1 ratio, T-AOC, TOS, OSI, GSH, MDA, and TOS/GSH ratio but lower SHBG, FSH, and HDL-C levels compared to the control group. The gene discussed is SHBG; the disease is acne.