Many lab abnormalities associated with heavy alcohol use, including elevation of aminotransferases, gamma-glutamyl transferase, and bilirubin, macrocytic anemia, and thrombocytopenia, are often found in patients with liver disease irrespective of etiology.27 Carbohydrate-deficient transferrin can reflect heavy drinking within the past 2–3 weeks, but lacks sensitivity and specificity in severe liver disease.28,29 Direct products of alcohol metabolism tend to be less affected by liver disease. The gene discussed is TF; the disease is liver disorder.