Genes related to cancer stem cells and tumorigenesis, such as KPNA2, ECT2, ERCC6L and TUBB4B, and the cell-cycle regulators DLGAP5, KIF2C and BUB3 (Christiansen and Dyrskjøt, 2013; Dharmapal et al., 2021; Gong et al., 2020; Pu et al., 2017; Silva and Bousbaa, 2022; Sun et al., 2017; Tsou et al., 2003) were also significantly upregulated in the CSPG+ group, and clustered well within the same area. This evidence concerns the gene BUB3 and cancer.