CV2/CRMP5‐IgG PND can have both central and peripheral nervous system manifestations, including myelopathy, limbic encephalitis, cranial neuropathies (most notably optic neuropathy), cerebellar ataxia, myasthenic syndromes, polyneuropathy, radiculopathy, and chorea.6, 8, 9, 10. Here, DPYSL5 is linked to Optic neuropathy.