CV2/CRMP5‐IgG PND can have both central and peripheral nervous system manifestations, including myelopathy, limbic encephalitis, cranial neuropathies (most notably optic neuropathy), cerebellar ataxia, myasthenic syndromes, polyneuropathy, radiculopathy, and chorea.6, 8, 9, 10. This evidence concerns the gene DPYSL5 and aceruloplasminemia.