CV2/CRMP5‐IgG PND can have both central and peripheral nervous system manifestations, including myelopathy, limbic encephalitis, cranial neuropathies (most notably optic neuropathy), cerebellar ataxia, myasthenic syndromes, polyneuropathy, radiculopathy, and chorea.6, 8, 9, 10. The gene discussed is DPYSL5; the disease is optic nerve disorder.