NOS2 and Alzheimer disease: Garzorz-Stark et al. (2016) described that NOS2 is significantly upregulated in lesional psoriatic skin compared to in healthy skin or AD. Indeed, we found that NOS2 is expressed more prominently and is more widely spread in the epidermis of the psoriasis model compared to the epidermis of the control HSE and the AD model (Fig. 3E,F).