IL22 and Alzheimer disease: AD models can be generated by adding TH2 cytokines such as IL-4 and IL-13, and TNF-α (Danso et al., 2014; De Vuyst et al., 2018; Kamsteeg et al., 2011), whereas psoriasis models are induced by treating skin models with cytokine cocktails based on IL-17, IL-22 and TNF-α.