JAK2 and cancer: Numerous metabolic canonical pathways (glucocorticoid receptor signaling and PPAR signaling), a cancer-related canonical pathway (regulation of epithelial-mesenchymal transition pathway), and immunity-related canonical pathways (role of JAK1, JAK2, and TYK2 in interferon signaling, IL-9 signaling, JAK/Stat signaling, etc.)were enriched (Figure 4I and File 5: Sheet 1).