PDPK1 and glioblastoma: For example, a previous study observed that in human glioblastoma cell lines, T98G and U87MG cells, the interference of human PDPK1 mRNA by siRNA decreased the phosphorylation level of human BAD protein (S112, S136, and S155) and activated cell death to suppress tumorigenesis (Desai et al., 2011).